Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells
نویسندگان
چکیده
منابع مشابه
B Cell Receptor Signaling in Human B Cells
B cells play an important role in the early phase of the immune response particularly in polysaccharide-encapsulated bacteria-induced responses, in which B and T cell cooperation is interfered. The mechanisms of these T cell-independent (TI) -antigen-induced B cell responses have been studied mainly in mice, but the responses and the role of BCR-mediated activation in human B cells are not know...
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CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor.
Mature B cells coexpress both IgM and IgD B-cell antigen receptor (BCR) classes, which are organized on the cell surface in distinct protein islands. The specific role of the IgD-BCR is still enigmatic, but it is colocalized with several other receptors on the B-cell surface, including the coreceptor CD19. Here, we report that the chemokine receptor CXCR4 is also found in proximity to the IgD-B...
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15 صفحه اولTranslocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling.
The cross-linking of the B cell Ag receptor (BCR) leads to the initiation of a signal transduction cascade in which the earliest events involve the phosphorylation of the immunoreceptor tyrosine-based activation motifs of Ig alpha and Ig beta by the Src family kinase Lyn and association of the BCR with the actin cytoskeleton. However, the mechanism by which BCR cross-linking initiates the casca...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v128.22.2037.2037